Contain 2 active ingredients: Irbesartan 300 mg & Hydrochlorothiazide 25 mg
Hydrochlorothiazide is a type of medicine known as a thiazide diuretic. Thiazide diuretics act in the kidneys, where they increase the production of urine. They work by causing the kidneys to increase the amount of salts, such as potassium and sodium, that are filtered out of the blood and into the urine. When these salts are filtered out of the blood by the kidneys, water is also drawn alongside. As hydrochlorothiazide increases the removal of salts from the blood, it also causes more water to be drawn out of the blood and into the urine.
Removing water from the blood decreases the volume of fluid circulating through the blood vessels, which decreases the pressure within the blood vessels. Hydrochlorothiazide therefore lowers blood pressure.
Irbesartan, which is a type of medicine called an angiotensin II receptor antagonist. (Irbesartan tablets are also available without a brand name, ie as the generic medicine.) Irbesartan lowers blood pressure by preventing the action of a hormone in the body called angiotensin II.
Angiotensin II is involved in regulating blood pressure and fluid balance. It has two main actions. It causes the blood vessels to narrow and the kidneys to retain salt and water, which increases the volume of fluid in the blood vessels.
Irbesartan blocks the receptors that angiotensin II acts on, and so prevents its actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This is the main mechanism by which the pressure in the blood vessels is lowered.
Blocking the actions of angiotensin II also increases the amount of fluid removed from the blood by the kidneys. This decreases the amount of fluid in the blood vessels, which also lessens the resistance and pressure in the blood vessels.
The combined overall effect of these changes is to lower the blood pressure, hence irbesartan is used to treat high blood pressure.
Irbesartan can also be used to protect the kidneys and slow down the decrease in kidney function in people with type 2 diabetes and high blood pressure.
What is it used for?
High blood pressure with no known cause (essential hypertension).
Size : 28 tablets / box
English instruction inside the box