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Mestinon 60 mg

3 or more : $53.99 6 or more : $52.99 12 or more : $50.99
  • Brand: Menarini
  • Product Code: MN_MTN
  • Availability: In Stock

Contain the active ingredient : Pyridostigmine Bromide, which is a type of medicine called an anticholinesterase. It works by prolonging the action of a neurotransmitter called acetylcholine.

Neurotransmitters are chemicals that are stored in nerve cells in the brain and nervous system. They are involved in transmitting messages between nerve cells. Acetylcholine is involved in transmitting nerve messages that control many of the processes that happen automatically in the body, ie without our voluntary control. It is also involved in transmitting the nerve messages to muscles that cause them to contract.

In order for the nerves to pass a message to a muscle, acetylcholine is released from the end of the nerve cell. It fits into acetylcholine receptors that are found on the muscle cells like a key into a lock. This causes changes in the muscle cells that cause the muscle to contract. The acetylcholine is then rapidly broken down by an enzyme called cholinesterase.

In the condition called myasthenia gravis the body's immune system destroys many of the acetylcholine receptors on the muscle cells. This means that the muscle becomes less responsive to nerve messages and as a result, the person experiences muscle weakness, particularly when they repeatedly try to use the same muscle.

Pyridostigmine stops cholinesterase from breaking down acetylcholine at the junctions between the nerves and the muscle cells. This prolongs the action of acetylcholine at the nerve endings and gives it more chance to act on the remaining acetylcholine receptors. Pyridostigmine thus increases the likelihood of a nerve signal being successfully transmitted to the muscle. It improves nerve transmission both to muscles that are under voluntary control, as well as those that are not, for example the muscle in the gut. It thus allows these muscles to function normally.

The benefits of pyridostigmine occur within 30 to 60 minutes but wear off in three to four hours, so the medicine should be taken at regular intervals throughout the day to improve muscle function in myasthenia gravis.

Pyridostigmine can also be used to improve nerve transmission to the muscle in the gut in people whose intestine is not working properly, or to the muscle in the bladder in people whose bladder is not working properly (for example following surgery).

Inactivity or temporary paralysis of the muscle in the intestine prevents the passage of food through the intestine and can lead to a blockage in the gut. Pyridostigmine increases the nerve messages to the gut that make it contract and helps it move food along.

Temporary paralysis of the muscle in the bladder makes it difficult to pass urine. Pyridostigmine increases the nerve messages to the bladder that make it contract, and this allows urination to happen.

What is it used for?

Myasthenia gravis.

Difficulty passing urine (urinary retention) after an operation.

Inactivity or temporary paralysis of the muscle in the intestines (paralytic ileus).

English instruction leaflet inside the box.

Size : 120 tablets / box