- Brand: MSD
- Product Code: MSD_VTR
- Availability: In Stock
Contain 2 active ingredients: Ezetimibe and Simvastatin . Both these medicines are used to lower cholesterol. They work in different and complementary ways.
For the sake of simplicity, there are two sorts of cholesterol; a 'bad' sort called low density lipoprotein (LDL) and a 'good' sort called high density lipoprotein (HDL). LDL is deposited in the arteries and increases the risk of heart disease by clogging and narrowing the arteries (atherosclerosis), while HDL actually protects the arteries against this.
Ezetimibe is a type of medicine called a cholesterol absorption inhibitor. It works by preventing cholesterol from being absorbed from the small intestine into the bloodstream. It prevents cholesterol and other plant sterols that are consumed in the diet from being absorbed into the bloodstream. It also prevents cholesterol that is released from the bile duct into the intestine from being reabsorbed into the bloodstream. The overall result is a reduction in cholesterol levels in the blood.
Simvastatin is a type of medicine called a statin. It works by reducing the production of LDL cholesterol by the liver. It does this by blocking the action of the enzyme in the liver (called HMG-CoA reductase) that is responsible for its production. This decreases the amount of cholesterol in the liver cells, which causes them to take up LDL cholesterol from the blood. The decreased cholesterol production and increased removal of LDL cholesterol from the blood ultimately results in lowered blood cholesterol levels.
Simvastatin also causes a small decrease in the production of other 'bad fats' in the blood called triglycerides, and a small increase in the level of HDL cholesterol. This results in lowered levels of 'bad fats' and raised levels of 'good fats' in the blood.
Statins have an important role in coronary heart disease. They reduce the risk of excess cholesterol being deposited in the major blood vessels of the heart (atherosclerosis). Any blockage in these blood vessels limits the amount of blood and therefore oxygen being carried to the heart muscle. This can cause chest pain (angina) and in severe cases can result in a heart attack (myocardial infarction) or stroke. Simvastatin has been shown to reduce the risk of these complications of atherosclerosis.
These medicines work in different ways, but they have an additive effect on high cholesterol levels. The combination is used to lower high cholesterol in people whose cholesterol has not been lowered sufficiently using a statin alone. Combining the medicines into one tablet aims to simplify treatment for those who need to take ezetimibe in combination with a statin to control their cholesterol.
What is it used for?
High blood cholesterol levels (primary hypercholesterolaemia).
Inherited high blood cholesterol levels (familial hypercholesterolaemia).
High levels of any or all of the fats in the blood, such as cholesterol, triglycerides and lipoproteins (mixed hyperlipidaemia).
Size : 30 tablets / box