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Xigduo XR 10 mg/1,000 mg

3 or more : $83.99 6 or more : $82.99 12 or more : $80.99
  • Brand: AstraZeneca
  • Product Code: AZ_XD10_1000
  • Availability: In Stock
Contains the active ingredients : Dapagliflozin 10 mg, Metformin HCl extended-release 1,000 mg 

In type 2 diabetes the cells in the body become resistant to the action of insulin. Insulin is the main hormone responsible for controlling the level of sugar (glucose) in the blood. It makes cells in the body remove sugar from the blood. When the cells are resistant to insulin this makes blood sugar levels rise too high.

Metformin is a type of antidiabetic medicine known as a biguanide. It works in a number of ways to decrease the amount of sugar in the blood. Firstly, it reduces the amount of sugar produced by cells in the liver. Secondly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Finally, it delays absorption of sugar from the intestines into the bloodstream after eatingso that there is less of a spike in blood sugar levels after meals.

Dapagliflozin works in the kidneys, where it allows the body to excrete excess glucose from the blood into the urine.

Normally, when the kidneys filter and clean the blood, glucose is filtered out of the blood at the same time. The glucose is then reabsorbed back into the blood by a mechanism called the sodium-glucose co-transporter 2 (SGLT2). The kidneys normally reabsorb glucose back into the blood even when the levels of glucose in the blood are too high, as in diabetes.

Dapagliflozin works by inhibiting the SGLT2 transporter. This allows excess glucose to be filtered out of the blood and excreted in the urine. This will reduce blood sugar levels.

Dapagliflozin has two other effects that may be of benefit for people with diabetes. Firstly, it may cause weight loss due to the loss of sugar from the body. Secondly, it causes a small increase in the amount of water being filtered out of the blood into the urine (diuresis). This may help to reduce blood pressure.

What is it used for?

Type 2 diabetes in adults aged 18 years and over.

Xigduo tablets are licensed for use in people with type 2 diabetes whose blood sugar is not controlled by the maximum tolerated dose of metformin alone or who are already taking metformin and dapagliflozin as separate tablets.

English instruction inside the box.

Size :  4 x 7's = 28 tablets/box