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Jardiance Duo 12.5 mg/1000 mg

3 or more : $162.99 6 or more : $161.99 12 or more : $160.99

Contain the active ingredient : Empagliflozin,12.5 mg & Metformin HCl 1,000 mg

In type 2 diabetes the cells in the body become resistant to the action of insulin. Insulin is the main hormone responsible for controlling the level of sugar (glucose) in the blood. It makes cells in the body remove sugar from the blood. When the cells are resistant to insulin this makes blood sugar levels rise too high.

Empagliflozin works in the kidneys, where it allows the body to excrete excess glucose from the blood into the urine.

Normally, when the kidneys filter and clean the blood, glucose is filtered out of the blood at the same time. The glucose is then reabsorbed back into the blood by a mechanism called the sodium-glucose co-transporter 2 (SGLT2). The kidneys normally reabsorb glucose back into the blood even when the levels of glucose in the blood are too high, as in diabetes.

Empagliflozin works by inhibiting the SGLT2 transporter. This allows excess glucose to be filtered out of the blood and excreted in the urine. This will reduce blood sugar levels.

Metformin HCl which  is a type of antidiabetic medicine called a biguanide. It works in a number of ways to lower blood sugar levels in people with type 2 diabetes.

Firstly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Secondly, it reduces the amount of sugar produced by cells in the liver. Finally, it delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals.

Metformin is taken regularly every day to help control blood sugar levels both between and directly after meals.

In polycystic ovary syndrome or PCOS many women have high insulin levels, and as a result their cells become resistant to the action of insulin. The high insulin levels also cause an increase in the male hormone testosterone. Both problems can cause some of the symptoms of PCOS, such as hair growth, weight gain, irregular periods and fertility problems.

As metformin improves the sensitivity of cells to insulin, this can help insulin levels to fall in PCOS. This has a knock-on effect of causing testosterone levels to fall. So although it's not licensed for this condition, metformin can be helpful in managing some of its symptoms. Your doctor can give you more information about this.

What is it used for?

Type 2 diabetes (non-insulin dependent diabetes) in adults aged 18 years and over.

Size :  60 tablets/box