Contain the active ingredient : Sitagliptin, which is a type of medicine called a dipeptidyl peptidase 4 (DPP-4) inhibitor. It is used to treat people with type 2 or non-insulin dependent diabetes (NIDDM).
Sitagliptin works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar (glucose) levels.
GLP-1 and GIP have four main actions that help to control blood glucose.
Firstly, they stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood. (Insulin is the main hormone responsible for controlling sugar levels in the blood. It causes cells in the body to remove sugar from the blood.)
GLP-1 also reduces the production of glucagon. (Glucagon is a hormone that normally increases glucose production by the liver.)
GLP-1 and GIP also reduce the rate at which food passes from the stomach into the intestines, which slows down the absorption of glucose from the gut into the bloodstream. Finally, they act on the brain to cause a feeling of fullness that reduces further food intake.
GLP-1 and GIP are normally broken down by an enzyme in the body called dipeptidyl peptidase 4. Sitaglipin works by binding to this enzyme and preventing it from breaking down the GLP-1 and GIP. This increases the levels of these hormones in the body and so increases their effect on controlling blood sugar.
What is it used for?
Type 2 diabetes (non-insulin dependent diabetes).
Januvia can be used on its own to improve blood sugar control in people whose blood sugar is not controlled by changes to their diet and exercise alone and who can't take metformin.
Size : 28 tablets /box