Contain the active ingredient : Telmisartan 80 mg, Amlodipine Besilate 5 mg, which is a type of medicine called an angiotensin II receptor antagonist. It works by preventing the action of a hormone in the body called angiotensin II.
Angiotensin II normally acts on special receptors in the body, with two main results. Firstly, it causes the peripheral blood vessels to narrow, and secondly, it stimulates the production of another hormone called aldosterone. Aldosterone causes salt and water to be retained by the kidneys, which increases the volume of fluid in the blood vessels.
Telmisartan blocks the receptors that angiotensin II acts on, and so prevents its actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This is the main mechanism by which the pressure in the blood vessels is lowered.
Blocking the actions of angiotensin II also reduces the action of aldosterone on the kidneys. The result of this is an increase in the amount of fluid removed from the blood by the kidneys. This decreases the amount of fluid in the blood vessels, which also lessens the resistance and pressure in the blood vessels.
The combined overall effect of these changes is to lower the blood pressure.
What is it used for?
High blood pressure with no known cause (essential hypertension).
Replacement Therapy: Patients receiving telmisartan and amlodipine from separate tablets may instead receive Twynsta containing the same component doses.
Add-On Therapy: Twynsta is indicated in patients whose blood pressure is not adequately controlled on telmisartan or amlodipine monotherapy.
Initial Therapy: Twynsta may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals. The choice of Twynsta as initial therapy for hypertension should be based on an assessment of potential benefits and risks.Reducing the risk of heart attack or stroke in people with a history of coronary heart disease, previous stroke or type 2 diabetes that has caused damage to any organs.
English instruction leaflet inside the box.
Size: 30 tablets /box